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Tumors derived from patients with gastric cancer were subcutaneously heterotransplanted into nude mice in order to study their tumorigenicity and malignant behavior. Of the gastric cancers, 45 were successfully transplanted a The tumorigenesis rate of Borrmann type 1 and 2 cancers Also, the tumorigenesis rate of differentiated carcinoma Spontaneous metastases from the subcutaneous tumors were observed in 5 of the 37 established tumor lines
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Protocol DOI: As a novel potential therapeutic strategy for cardiac disease, cell transplantation therapy has been extensively investigated in experimental studies and clinical trials. Although encouraging results have been demonstrated, a number of critical.
We have established a new xenogeneic animal model of leptomeningeal metastasis LM by intracisternal inoculation of human CEM T-cell lymphoma into nude rats, and used it to evaluate the anti-lymphoma efficacy of an anti-CD7 ricin A chain immunotoxin DA7. Histopathologically, all eight sham-treated and five of eight DA7 treated animals showed typical features of LM with multilayers of tumor cells along the whole subarachnoid space and the ventricular walls, as well as subependymal and diffuse parenchymal tumor cell infiltration. Three DA7 treated animals were free of tumor. The third tumor-free animal suddenly died on day Histology revealed viral myocarditis.